Almstead, N. G.: search on Z-Library

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1

Novel l-Xylose Derivatives as Selective Sodium-Dependent Glucose Cotransporter 2 (SGLT2) Inhibitors for the Treatment of Type 2 Diabetes

Goodwin, Nicole C., Mabon, Ross, Harrison, Bryce A., Shadoan, Melanie K., Almstead, Zheng Y., Xie, Yiling, Healy, Jason, Buhring, Lindsey M., DaCosta, Christopher M., Bardenhagen, Jennifer

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 762 KB

english, 2009

2

Spectroscopic studies on the TiCl4-promoted reaction of allylsilanes with aldehydes and α,β-enones

Scott E. Denmark, Neil G. Almstead

Journal:

Year:

1992

Language:

english

File:

PDF, 1.07 MB

english, 1992

3

Comparison of the pharmacology of hydroxamate- and carboxylate-based matrix metalloproteinase inhibitors (MMPIs) for the treatment of osteoarthritis

M. J. Janusz, E. B. Hookfin, K. K. Brown, L. C. Hsieh, S. A. Heitmeyer, Y. O. Taiwo, M. G. Natchus, S. Pikul, N. G. Almstead, B. De S. X. Peng, T. R. Baker, V. Patel

Journal:

Inflammation Research

Year:

2006

Language:

english

File:

PDF, 100 KB

english, 2006

4

Industrial Safety || Safety in Building Construction

Journal:

The ANNALS of the American Academy of Political and Social Science

Year:

1926

Language:

english

File:

PDF, 809 KB

english, 1926

5

Safety in Building Construction

Journal:

The ANNALS of the American Academy of Political and Social Science

Year:

1926

Language:

english

File:

PDF, 352 KB

english, 1926

6

Synthesis and biological testing of non-Fluorinated analogues of levofloxacin

Jeffrey L. Gray, Ji-In K. Almstead, Corey P. Gallagher, X.Eric Hu, Nick K. Kim, Cynthia J. Taylor, Tracy L. Twinem, Cynthia D. Wallace, Benoit Ledoussal

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 150 KB

english, 2003

7

Safety, Tolerability, and Pharmacokinetics of PTC124, a Nonaminoglycoside Nonsense Mutation Suppressor, Following Single- and Multiple-Dose Administration to Healthy Male and Female Adult Volunteers

Hirawat, Samit, Welch, Ellen M., Elfring, Gary L., Northcutt, Valerie J., Paushkin, Sergey, Hwang, Seongwoo, Leonard, Eileen M., Almstead, Neil G., Ju, William, Peltz, Stuart W., Miller, Langdon L.

Journal:

Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 337 KB

english, 2007

8

miR-29 and miR-30 regulate B-Myb expression during cellular senescence

Martinez, I., Cazalla, D., Almstead, L. L., Steitz, J. A., DiMaio, D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1019 KB

english, 2011

9

ChemInform Abstract: Oxazolidinone to Succinamide: A Novel Rearrangement Reaction.

Menyan Cheng, Biswanath De, Christopher T. Wahl, Neil G. Almstead, Michael G. Natchus, Stanislaw Pikul

Journal:

Year:

1999

File:

PDF, 27 KB

1999

10

Identification of PTC725, an Orally Bioavailable Small Molecule That Selectively Targets the Hepatitis C Virus NS4B Protein

Gu, Z., Graci, J. D., Lahser, F. C., Breslin, J. J., Jung, S. P., Crona, J. H., McMonagle, P., Xia, E., Liu, S., Karp, G., Zhu, J., Huang, S., Nomeir, A., Weetall, M., Almstead, N. G., Peltz, S. W., T

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2013

Language:

english

File:

PDF, 2.18 MB

english, 2013

11

1,4-radical elimination in cyclohexene systems: A model for the chorismate synthase reaction

Bernd Giese, Neil G. Almstead

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 302 KB

english, 1994

12

An investigation into the total synthesis of clerocidin: stereoselective synthesis of a clerodane intermediate

Ji-In Kim Almstead, Thomas P. Demuth Jr., Benoit Ledoussal

Journal:

Tetrahedron: Asymmetry

Year:

1998

Language:

english

File:

PDF, 139 KB

english, 1998

13

Development of New Hydroxamate Matrix Metalloproteinase Inhibitors Derived from Functionalized 4-Aminoprolines

Natchus, Michael G., Bookland, Roger G., De, Biswanath, Almstead, Neil G., Pikul, Stanislaw, Janusz, Michael J., Heitmeyer, Sandra A., Hookfin, Erin B., Hsieh, Lily C., Dowty, Martin E., Dietsch, Char

Journal:

Journal of Medicinal Chemistry

Year:

2000

Language:

english

File:

PDF, 398 KB

english, 2000

14

Primary human cervical carcinoma cells require human papillomavirus E6 and E7 expression for ongoing proliferation

Thomas G. Magaldi, Laura L. Almstead, Stefania Bellone, Edward G. Prevatt, Alessandro D. Santin, Daniel DiMaio

Journal:

Year:

2012

Language:

english

File:

PDF, 990 KB

english, 2012

15

Discovery of novel HCV inhibitors: Synthesis and biological activity of 6-(indol-2-yl)pyridine-3-sulfonamides targeting hepatitis C virus NS4B

Zhang, Xiaoyan, Zhang, Nanjing, Chen, Guangming, Turpoff, Anthony, Ren, Hongyu, Takasugi, James, Morrill, Christie, Zhu, Jin, Li, Chunshi, Lennox, William, Paget, Steven, Liu, Yalei, Almstead, Neil, G

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 3.01 MB

english, 2013

16

Discovery and optimization of small molecule splicing modifiers of survival motor neuron 2 (SMN2) as a treatment for spinal muscular atrophy

Woll, Matthew G, Qi, Hongyan, Turpoff, Anthony, Zhang, Nanjing, Zhang, Xiaoyan, Chen, Guangming, Li, Chunshi, Huang, Song, Yang, Tianle, Moon, Young-Choon, Lee, Chang-Sun, Choi, Soongyu, Almstead, Nei

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 727 KB

english, 2016

17

Synthesis and Biological Testing of Non-Fluorinated Analogues of Levofloxacin.

Jeffrey L. Gray, Ji-In K. Almstead, Corey P. Gallagher, X. Eric Hu, Nick K. Kim, Cynthia J. Taylor, Tracy L. Twinem, Cynthia D. Wallace, Benoit Ledoussal

Journal:

Year:

2003

File:

PDF, 124 KB

2003

18

The development of new carboxylic acid-based MMP inhibitors derived from a cyclohexylglycine scaffold

Joshua S. Tullis, Matthew J. Laufersweiler, John C. VanRens, Michael G. Natchus, Roger G. Bookland, Neil G. Almstead, Stanislaw Pikul, Biswanath De, Lily C. Hsieh, Michael J. Janusz, Todd M. Branch, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

19

Structure–Activity Relationship (SAR) Optimization of 6-(Indol-2-yl)pyridine-3-sulfonamides: Identification of Potent, Selective, and Orally Bioavailable Small Molecules Targeting Hepatitis C (HCV) NS4B

Zhang, Nanjing, Zhang, Xiaoyan, Zhu, Jin, Turpoff, Anthony, Chen, Guangming, Morrill, Christie, Huang, Song, Lennox, William, Kakarla, Ramesh, Liu, Ronggang, Li, Chunshi, Ren, Hongyu, Almstead, Neil,

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 650 KB

english, 2014

20

Interâgroup conflict in a cooperatively breeding bird: New insights into âhome field advantageâ

Almstead, Danielle K., Savagian, Amanda G., Smith, Maria G., Riehl, Christina

Journal:

Year:

2020

File:

PDF, 739 KB

2020

21

Gas chromatographic–mass spectrometric analysis of hydroxylamine for monitoring the metabolic hydrolysis of metalloprotease inhibitors in rat and human liver microsomes

Sean X. Peng, Michael J. Strojnowski, Joanna K. Hu, Bill J. Smith, Thomas H. Eichhold, Kenneth R. Wehmeyer, Stanislaw Pikul, Neil G. Almstead

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1999

Language:

english

File:

PDF, 136 KB

english, 1999

22

Potent and Selective Carboxylic Acid-Based Inhibitors of Matrix Metalloproteinases

Pikul, Stanislaw, Ohler, Norman E., Ciszewski, Greg, Laufersweiler, Michael C., Almstead, Neil G., De, Biswanath, Natchus, Michael G., Hsieh, Lily C., Janusz, Michael J., Peng, Sean X., Branch, Todd M

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 54 KB

english, 2001

23

Stereoselective opening of chiral dioxane acetals. Nucleophile dependence

Denmark, Scott E., Almstead, Neil G.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 398 KB

english, 1991

24

Flash Photolysis of .alpha.-Diazonaphthoquinones in Aqueous Solution: Determination of Rates and Equilibria for Keto-Enol Tautomerization of 1-Indene-3-carboxylic Acid

Almstead, Ji In Kim, Urwyler, Bernhard, Wirz, Jakob

Journal:

Journal of the American Chemical Society

Year:

1994

Language:

english

File:

PDF, 873 KB

english, 1994

25

Oxy-Allyl Cation Catalysis: An Enantioselective Electrophilic Activation Mode

Liu, Chun, Oblak, E. Zachary, Vander Wal, Mark N., Dilger, Andrew K., Almstead, Danielle K., MacMillan, David W. C.

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 659 KB

english, 2016

26

88 POSTER Identification of a small molecule drug that post transcriptionally inhibits production of VEGF protein by targeting 5′ UTR-dependent translation

C. Trotta, L. Cao, C. Romfo, J. Bombard, N. Almstead, J. Colacino, J. Babiak, S. Peltz, T. Davis

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 58 KB

english, 2006

27

The origin of stereoselective opening of chiral dioxane and dioxolane acetals: solution structure of their Lewis acid complexes

Denmark, Scott E., Willson, Timothy M., Almstead, Neil G.

Journal:

Journal of the American Chemical Society

Year:

1989

Language:

english

File:

PDF, 407 KB

english, 1989

28

Oxazolidinone to succinamide: a novel rearrangement reaction

Menyan Cheng, Biswanath De, Christopher T. Wahl, Neil G. Almstead, Michael G. Natchus, Stanislaw Pikul

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 155 KB

english, 1999

29

Stereochemical Studies on the Addition of Allylsilanes to Aldehydes. The SE' Component

Denmark, Scott E., Almstead, Neil G.

Journal:

Journal of Organic Chemistry

Year:

1994

Language:

english

File:

PDF, 359 KB

english, 1994

30

On the stereoselectivity opening of achiral dioxane acetals

Denmark, Scott E., Almstead, Neil G.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 1.74 MB

english, 1991

31

ChemInform Abstract: Spectroscopic Studies on the TiCl4-Promoted Reaction of Allylsilanes with Aldehydes and Î±,Î²-Enones.

DENMARK, S. E., ALMSTEAD, N. G.

Journal:

Year:

2010

File:

PDF, 31 KB

2010

32

On the stereochemical course of the addition of allylsilanes to aldehydes

Scott E. Denmark, Eric J. Weber, Neil G. Almstead, Larry M. Wolf

Journal:

Year:

2012

Language:

english

File:

PDF, 1.37 MB

english, 2012

33

Synthesis of 1,4-Disubstituted Pyrazolo[3,4-d]pyrimidines from 4,6-Dichloropyrimidine-5-carboxaldehyde: Insights into Selectivity and Reactivity

Morrill, Christie, Babu, Suresh, Almstead, Neil, Moon, Young-Choon

Journal:

Year:

2013

Language:

english

File:

PDF, 323 KB

english, 2013

34

ChemInform Abstract: The Next Generation of MMP Inhibitors: Design and Synthesis

Biswanath De, Michael G. Natchus, Menyan Cheng, Stanislaw Pikul, Neil G. Almstead, Yetunde O. Taiwo, Catherine E. Snider, Longyin Chen, Bobby Barnett, Fei Gu, et al. et al.

Journal:

Year:

1999

File:

PDF, 26 KB

1999

35

Design, Synthesis, and Biological Evaluation of Potent Thiazine- and Thiazepine-Based Matrix Metalloproteinase Inhibitors

Almstead, Neil G., Bradley, Rimma S., Pikul, Stanislaw, De, Biswanath, Natchus, Michael G., Taiwo, Yetunde O., Gu, Fei, Williams, Lisa E., Hynd, Barbara A., Janusz, Michael J., Dunaway, C. Michelle, M

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 507 KB

english, 1999

36

Discovery of N-(4′-(indol-2-yl)phenyl)sulfonamides as novel inhibitors of HCV replication

Chen, Guangming, Ren, Hongyu, Turpoff, Anthony, Arefolov, Alexander, Wilde, Richard, Takasugi, James, Khan, Atiyya, Almstead, Neil, Gu, Zhengxian, Komatsu, Takashi, Freund, Connie, Breslin, Jamie, Col

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 1.03 MB

english, 2013

37

4-Hydroxy-2-pyridones: Discovery and evaluation of a novel class of antibacterial agents targeting DNA synthesis

Arnold, Michael A., Gerasyuto, Aleksey I., Wang, Jiashi, Du, Wu, Gorske, Yi Jin Kim, Arasu, Tamil, Baird, John, Almstead, Neil G., Narasimhan, Jana, Peddi, Srinivasa, Ginzburg, Olya, Lue, Stanley W.,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 2.24 MB

english, 2017

38

Phase 1 Study of Safety, Tolerability, and Pharmacokinetics of PTC299, an Inhibitor of Stress-Regulated Protein Translation

Weetall, Marla, Davis, Thomas, Elfring, Gary, Northcutt, Valerie, Cao, Liangxian, Moon, Young-Choon, Riebling, Peter, Dali, Mandar, Hirawat, Samit, Babiak, John, Colacino, Joseph, Almstead, Neil, Spie

Journal:

Clinical Pharmacology in Drug Development

Year:

2016

Language:

english

File:

PDF, 661 KB

english, 2016

39

Design, Synthesis, and Biological Evaluation of Matrix Metalloproteinase Inhibitors Derived from a Modified Proline Scaffold

Cheng, Menyan, De, Biswanath, Almstead, Neil G., Pikul, Stanislaw, Dowty, Martin E., Dietsch, Charles R., Dunaway, C. Michelle, Gu, Fei, Hsieh, Lily C., Janusz, Michael J., Taiwo, Yetunde O., Natchus,

Journal:

Journal of Medicinal Chemistry

Year:

1999

Language:

english

File:

PDF, 282 KB

english, 1999

40

ChemInform Abstract: Selective Synthesis of 1-Substituted 4-Chloropyrazolo[3,4-d]pyrimidines.

Babu, Suresh, Morrill, Christie, Almstead, Neil G., Moon, Young-Choon

Journal:

Year:

2013

File:

PDF, 33 KB

2013

41

Chemoselective Reactions of 4,6-Dichloro-2-(methylsulfonyl)pyrimidine and Related Electrophiles with Amines

Baiazitov, Ramil, Du, Wu, Lee, Chang-Sun, Hwang, Seongwoo, Almstead, Neil, Moon, Young-Choon

Journal:

Year:

2013

Language:

english

File:

PDF, 383 KB

english, 2013

42

Discovery of 2-(4-sulfonamidophenyl)-indole 3-carboxamides as potent and selective inhibitors with broad hepatitis C virus genotype activity targeting HCV NS4B

Zhang, Nanjing, Turpoff, Anthony, Zhang, Xiaoyan, Huang, Song, Liu, Yalei, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Pichardo, John, Colacino, Joseph, Lahser,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 2.77 MB

english, 2015

43

6-(Azaindol-2-yl)pyridine-3-sulfonamides as potent and selective inhibitors targeting hepatitis C virus NS4B

Chen, Guangming, Ren, Hongyu, Zhang, Nanjing, Lennox, William, Turpoff, Anthony, Paget, Steven, Li, Chunshi, Almstead, Neil, Njoroge, F. George, Gu, Zhengxian, Graci, Jason, Jung, Stephen P., Colacino

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2015

Language:

english

File:

PDF, 383 KB

english, 2015

44

miR-29 and miR-30 regulate B-Myb expression during cellular senescence

Ivan Martinez, Demian Cazalla, Laura L. Almstead, Joan A. Steitz and Daniel DiMaio

Journal:

Proceedings of the National Academy of Sciences

Year:

2011

Language:

english

File:

PDF, 1.57 MB

english, 2011

45

ChemInform Abstract: The Origin of Stereoselective Opening of Chiral Dioxane and Dioxolane Acetals: Solution Structure of Their Lewis Acid Complexes.

DENMARK, S. E., WILLSON, T. M., ALMSTEAD, N. G.

Journal:

Year:

1990

File:

PDF, 94 KB

1990

46

The Next Generation of MMP Inhibitors: Design and Synthesis

BISWANATH DE, MICHAEL G. NATCHUS, MENYAN CHENG, STANISLAW PIKUL, NEIL G. ALMSTEAD, YETUNDE O. TAIWO, CATHERINE E. SNIDER, LONGYIN CHEN, BOBBY BARNETT, FEI GU, MARTIN DOWTY

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 711 KB

english, 1999

47

Selective Synthesis of 1-Substituted 4-Chloropyrazolo[3,4- d ]pyrimidines

Babu, Suresh, Morrill, Christie, Almstead, Neil G., Moon, Young-Choon

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 181 KB

english, 2013

48

Design and synthesis of conformationally-constrained MMP inhibitors

Michael G. Natchus, Menyan Cheng, Christopher T. Wahl, Stanislaw Pikul, Neil G. Almstead, Rimma S. Bradley, Yetunde O. Taiwo, Glen E. Mieling, C.Michelle Dunaway, Catherine E. Snider, John M. McIver,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 272 KB

english, 1998

49

Discovery of (3 S )-Amino-(4 R )-ethylpiperidinyl Quinolones as Potent Antibacterial Agents with a Broad Spectrum of Activity and Activity against Resistant Pathogens

Hu, X. Eric, Kim, Nick K., Gray, Jeffrey L., Almstead, Ji-In K., Seibel, William L., Ledoussal, Benoit

Journal:

Journal of Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 170 KB

english, 2003

50

ChemInform Abstract: Synthesis of 1,4-Disubstituted Pyrazolo[3,4-d]pyrimidines from 4,6-Dichloropyrimidine-5-carboxaldehyde: Insights into Selectivity and Reactivity.

Morrill, Christie, Babu, Suresh, Almstead, Neil G., Moon, Young-Choon

Journal:

Year:

2013

File:

PDF, 36 KB

2013

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